How it works, simply
It activates an intestinal receptor involved in fluid secretion.
What the evidence tells us
An oral bowel treatment should not be interpreted as an injectable peptide or general digestive supplement.
Watch with PEP 7
A short introduction; the sources and limitations remain important.
Open video guide
Video guides are coming soon.
Risks and open questions
- Diarrhea and dehydration are important risks.
- The label contains a pediatric dehydration warning and age-specific restrictions.
Research and education only. PepGuide does not recommend medicines, doses or protocols.
Technical details and study context
Mechanism: Activates intestinal guanylate cyclase-C in a pH-sensitive manner.
Sponsor or developer: Bausch Health
Studied or labeled topics: Chronic idiopathic constipation, IBS-C
Commercial blend names and research vials do not inherit a medicine’s approval or manufacturing controls.
Sources and review dates
- DailyMed: TRULANCE IMMEDIATE RELEASE prescribing information ↗ · Regulator · Apr 05, 2024
Product labels and further research
These directories help locate records. They are not individual studies supporting every statement.
Readability updated October 10, 2026. Evidence review: October 10, 2026 (linked label: purpose and selected risks). A wording update is not a new clinical review.